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Details of Project:

Grant Name: FRGS 2014-2
Granting Body: Ministry of Higher Education (MOE-KPM)
Research Title: Evaluation of safety profile of a Fixed dose combination of Antidiabetic and Antihypertensive drug by toxicity profiling and pharmacokinetic interaction study.

Allocated Amount: RM 82,000
Project Leader: Dr. Arindam Das

Team Members:
1. Dr Pinaki Sengupta
2. Puan Norhaziland Fati Bt Mohd Zaid
3. Dr Faridah Mohd Said
4. Dr Uttam Kumar Mandal(IIUM)
5. Dr Bappaditya Chatterjee (IIUM)

Summary of Proposal:
Hypertension is a major contributor to cardiovascular mortality in diabetic subjects. Hence, it is necessary to include antihypertensive medication in the antidiabetic therapy regimen for effective control of complications in diabetes. In the present investigation, safety profile of the Fixed Dose Combination (FDC) of Pioglitazone, antidiabetic and Telmisartan, an antihypertensive will be evaluated.

Collaborative Research

Collaboration with: International Islamic University of Malaysia
Grant Name: FRGS 2014/1
Granting Body: Ministry of Higher Education (MOE- KPM)
Research Title: Papain Loaded Solid Lipid Nan particles as an Adjuvant Therapy for Colorectal Cancer

Allocated Amount: RM 94,608
Project Leader: Dr. Satheesh Babu Natarajan

Team Members:
1. Mr. Shah Mashood Ahmad (Faculty of Pharmacy)
2. Dr. Nor AshikeenBinti Abd Mokti (Faculty of Medicine)
3. Dr. Norhazira Binti Abdul Rahim (Faculty of Medicine)
4. Mrs. Suriyakala (Faculty of Medicine)
5. Dr. Kathiresan (AIMST University)

Summary of Proposal:
Current developments on Solid Lipid Nano particles (SLN) have gained special attention on cancer chemotherapy. In this research, papain is proposed as a novel adjuvant therapy for the treatment of colorectal cancer. Papain is aproteolytic enzyme extracted from Carica papaya, degrades the protective fibrin layer of cancer cells. The main aim of this proposal is to target the papain loaded SLN delivery system to specifically colorectal cancer cells where they will exert the EPR effect and cleaving the fibrin layer that protect by the cancer cells.

Collaborative Research
Collaboration with: University Malaya
Title of Research: Formulation of Nanoparticles from Herbal Extracts for Cancer Therapy.
Co-Investigator: Dr. Satheesh Babu Natarajan